Helene Langevin a research professor of neurology from University of Vermont found that most of the Qi points are located in the areas of inter-muscular or intramuscular connective tissue planes. In other words the Qi points are located in areas where fascia planes or network converges. They showed that acupuncture points mostly lie along the fascia planes between muscles or between a muscle and bone or tendon. When a needle is inserted along the fascia plane, it will first penetrate through skin's dermis & subcutaneous tissue, then through deeper interstitial connective tissue. They hypothesized that the Qi meridians are the representation of a network of fascia. A blockage of Qi can be viewed as an alteration in fascia composition. Acupuncture points correspond to the sites where fascia network converges. Thus needling or pressure at the acupuncture or trigger points will have more prominent effect because a point represents convergence of several fascia plane or lines. Thus manipulation produces changes in the cellular level that can propagate along the fascia network (Langevin & Yandow, 2002).